Product Description: This volume collects the contributions to the “Computational Grids for Italian Astrophysics: Status and Perspectives” workshop, held at INAF headquarters, Rome, in November 2005. The workshop aimed at taking a snapshot of the status within the Italian astrophysical community of the development and usage of computational and data Grid(s), with particular reference to the status of the Grid.it (especially work-package 10, dedicated to astrophysical applications) and DRACO projects. The results obtained by the scientists participating in the two projects were summarised, to evaluate the effectiveness of the porting of scientific applications on the Grid, to recognise possible improvements, to foster cross-fertilisation with other sciences involved in Grid processing, to bring the requirements of astronomers to the attention of middleware developers and, maybe most important, to disseminate results so as to allow fellow astronomers to make use of the Grid. An attempt to define the roadmap for the future was also made, to understand which resources are needed and how to procure them. The workshop ideally closed a complete loop initiated in July 2003, when a first workshop called “Grids in Astrophysics and the Virtual Observatory” was organised. Some two years of nitty-gritty hard work and experience based on trial-and-error have shown that Grids are actually useful and have found application in many fields of astrophysical research, ranging from theoretical simulations to data processing, from distributed databases to planning of space missions.